Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-NQO1 Rabbit mAb [71F09]
抗NQO1兔单克隆抗体 [71F09]
Cat. No.
A52244
Clone No. 71F09
SynonymsNQO1, DT-diaphorase, NAD(P)H dehydrogenase [quinone] 1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
31 kDa
Observed MW
31 kDa
Clonality
Monoclonal
Clone No.
71F09
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NQO1
Protein Name
NAD(P)H quinone dehydrogenase-1
Background
NQO1 (NAD(P)H quinone dehydrogenase 1) is cytosolic phase-II detoxification oxidoreductase family protein responsible for quinone detoxification and anti-oxidant defense. Using NAD(P)H as co-factor, NQO1 catalyzes two-electron reduction of quinones to prevent semiquinone-radical formation and mitigate oxidative damage. Transcriptionally controlled by Nrf2, NQO1 represents canonical downstream effector of antioxidant response. It metabolizes xenobiotics and shields cells from chemical and oxidative insult. NQO1 is frequently overexpressed in tumors to counteract oxidative microenvironment; certain small-molecule prodrugs are bio-activated in NQO1-high tumor cells. Loss-of-function polymorphism of NQO1 impairs detoxification capacity and increases disease susceptibility.
Localization
Cytoplasm
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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