Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-NRAS Rabbit mAb [03H82]
抗NRAS兔单克隆抗体 [03H82]
Cat. No.
A52245
Clone No. 03H82
SynonymsNRAS, NRAS proto-oncogene, gsp oncogene
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
22 kDa
Observed MW
22 kDa
Clonality
Monoclonal
Clone No.
03H82
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NRAS
Protein Name
NRAS proto-oncogene, GTPase
Background
NRAS (NRAS proto-oncogene, GTPase) belongs to RAS small-GTPase family and functions as molecular switch governing proliferation and survival signaling. GTP-bound NRAS is active and triggers downstream RAF-MEK-ERK and PI3K cascades; GTP hydrolysis converts it into GDP-bound inactive conformation. Somatic point mutations (e.g. Q61) impair intrinsic GTPase activity and lock NRAS in constitutively active state, driving melanoma, leukemia and thyroid carcinoma. Wild-type NRAS responds to growth-factor cues and orchestrates normal cell-cycle progression. NRAS shares partial functional redundancy with KRAS and HRAS yet exhibits tissue-specific mutation profiles; NRAS-mutated tumors display distinct prognosis and therapeutic response compared with other RAS isoforms.
Localization
Cell membrane
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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