Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Nrf2 Rabbit mAb [21F22]
抗Nrf2兔单克隆抗体 [21F22]
Cat. No.
A52246
Clone No. 21F22
SynonymsNrf2, NFE2L2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
68 kDa
Observed MW
100 kDa
Clonality
Monoclonal
Clone No.
21F22
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NFE2L2
Protein Name
Nuclear factor erythroid-2-related factor-2
Background
Nrf2 (NFE2-like bZIP transcription factor 2) is bZIP leucine-zipper transcription-factor family protein acting as master regulator of cellular antioxidant and phase-II detoxification response. Under basal conditions Nrf2 interacts with KEAP1 for continuous ubiquitination and degradation. Oxidative or electrophilic stress modifies KEAP1, enabling Nrf2 stabilization and nuclear import. Nrf2 heterodimerizes with small Maf proteins, binds antioxidant-response-element (ARE) and up-regulates cytoprotective genes such as HO-1 and NQO1 to counteract ROS and xenobiotic injury. Dysregulated Nrf2 signaling links to inflammation, neurodegeneration and cancer; constitutive Nrf2 stabilization confers chemoresistance in malignancies. Nucleo-cytoplasmic partitioning of Nrf2 indicates pathway activation status.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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