Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Oct-3/4 Rabbit mAb [50G69]
抗Oct-3/4兔单克隆抗体 [50G69]
Cat. No.
A52248
Clone No. 50G69
SynonymsOct-3/4, Oct-4, Oct3/4, OCT4, Octamer binding factor 4
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
39 kDa
Observed MW
45 kDa
Clonality
Monoclonal
Clone No.
50G69
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
POU5F1
Protein Name
Octamer-binding transcription factor-4
Background
POU5F1 (Oct3/4, POU class 5 homeobox 1) belongs to POU homeobox transcription-factor family and sustains pluripotency and self-renewal of embryonic stem cells. As core pluripotency regulator, Oct3/4 cooperates with Sox2 and Nanog, binds Oct-Sox cis-elements to activate stem-ness programs and repress differentiation-associated genes. Its expression is restricted to early embryo, ESC and iPSC. Dosage of Oct3/4 delicately controls stem-cell fate; either elevation or reduction induces differentiation. It is nearly absent in most adult tissues but re-activated in cancer stem cells to sustain oncogenic stemness.
Localization
Nucleus
Research Area
干细胞
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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