Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Oct-2 Rabbit mAb [38D49]
抗Oct-2兔单克隆抗体 [38D49]
Cat. No.
A52249
Clone No. 38D49
SynonymsOct-2, OCT2; OTF-2; OTF2; NF-A2; Oct2a; Oct2b; Octamer-binding protein 2; Octamer-binding transcription factor 2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; POU2F2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
51 kDa
Observed MW
65 kDa
Clonality
Monoclonal
Clone No.
38D49
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
POU2F2
Protein Name
Octamer-binding transcription factor-2
Background
POU2F2 (Oct-2, POU class 2 homeobox 2) belongs to POU homeobox transcription factor family and governs B-lymphocyte development and immune-gene transcription. Predominantly expressed throughout B-cell lineage from pro-B cell to plasma cell, Oct-2 binds promoters and enhancers of immunoglobulin genes to promote antibody-related transcription. Cooperating with co-activator OCA-B, it controls immunoglobulin heavy- and light-chain expression, supporting B-cell differentiation, class-switch recombination and plasma-cell antibody secretion. It also participates in neuronal transcriptional regulation. Oct-2 ablation causes B-cell developmental arrest and humoral immunodeficiency. Aberrant overexpression of Oct-2 occurs in B-cell lymphoma and serves as pathological biomarker.
Localization
Nucleus
Research Area
干细胞
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:400-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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