Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Optineurin Rabbit mAb [16G94]
抗Optineurin兔单克隆抗体 [16G94]
Cat. No.
A52250
Clone No. 16G94
SynonymsOptineurin, Optineurin-1, OPTN1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
63 kDa
Observed MW
74 kDa
Clonality
Monoclonal
Clone No.
16G94
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
OPTN
Protein Name
Optineurin
Background
OPTN (Optineurin) is a multi-domain adaptor-protein family executing selective autophagy, membrane trafficking and negative modulation of inflammatory signaling. As cytosolic scaffold protein equipped with ubiquitin-binding domains, optineurin recognizes ubiquitinated substrates and damaged organelles to drive selective autophagic clearance of mitochondria and intracellular pathogens. It negatively restrains NF-κB cascade to prevent excessive inflammation and participates in Golgi vesicle trafficking. Mutations in OPTN are linked to open-angle glaucoma and motor-neuron disease. Loss-of-function leads to accumulation of damaged mitochondria and sustained inflammatory signaling. Altered optineurin expression modulates cell survival in tumor and neurodegenerative models.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:500
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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