Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CDKN2A/p14ARF Rabbit mAb [30F79]
抗CDKN2A/p14ARF兔单克隆抗体 [30F79]
Cat. No.
A52251
Clone No. 30F79
SynonymsCDKN2A/p14ARF, p14-ARF, p16INK4a, p14ARF (human), MTSS1, INK4a/ARF
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
14 kDa
Observed MW
16 kDa
Clonality
Monoclonal
Clone No.
30F79
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDKN2A
Protein Name
Cyclin-dependent kinase inhibitor-2A (ARF isoform)
Background
p14ARF (CDKN2A, cyclin-dependent kinase inhibitor 2A, ARF isoform) is an alternative-reading-frame product of tumor-suppressor CDKN2A, responsible for p53 stabilization, cell-cycle arrest and oncogenic surveillance. Translated from distinct reading frame of CDKN2A, p14ARF does not directly inhibit cyclin-dependent kinases. It binds and sequesters MDM2 to block MDM2-dependent p53 ubiquitination-degradation, elevating p53 abundance to trigger cell-cycle arrest and apoptosis upon oncogenic or genotoxic stress. Oncogenic activation up-regulates p14ARF as a critical tumor-suppressive checkpoint. Frequent locus deletion and epigenetic silencing of CDKN2A occur in diverse human malignancies.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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