Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-p16 INK4A Rabbit mAb [46F87]
抗p16 INK4A兔单克隆抗体 [46F87]
Cat. No.
A52252
Clone No. 46F87
Synonymsp16 INK4A, p16-INK4A, p16INK4a, MTSS1, INK4a, p16
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
17 kDa
Observed MW
17 kDa
Clonality
Monoclonal
Clone No.
46F87
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDKN2A
Protein Name
Cyclin-dependent kinase inhibitor-2A (INK4A isoform)
Background
p16INK4A (CDKN2A, cyclin-dependent kinase inhibitor 2A) belongs to cyclin-dependent kinase inhibitor family, inhibiting CDK4/6 to trigger G1-phase cell-cycle arrest and mediate cellular senescence. p16INK4A directly binds CDK4 and CDK6, disrupts CDK-Cyclin-D assembly, prevents Rb hyper-phosphorylation and preserves Rb tumor-suppressive function to block G1-to-S transition. It serves as canonical senescence biomarker with strong induction in senescent cells. Deletion or silencing of CDKN2A releases proliferative restraint and promotes oncogenesis. In HPV-driven tumors, viral E7 antagonizes Rb and induces compensatory p16INK4A overexpression, making p16INK4A a diagnostic marker for cervical lesions.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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