Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-p21 Rabbit mAb [82F87]
抗p21兔单克隆抗体 [82F87]
Cat. No.
A52253
Clone No. 82F87
Synonymsp21, WAF1, CIP1, SDI1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
18 kDa
Observed MW
18 kDa
Clonality
Monoclonal
Clone No.
82F87
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDKN1A
Protein Name
Cyclin-dependent kinase inhibitor-1A
Background
p21 (CDKN1A, cyclin-dependent kinase inhibitor 1A) is a broad-spectrum CDK-inhibitor family protein mediating cell-cycle repression, DNA-damage response and senescence control. p21 inhibits multiple Cyclin-CDK assemblies, prevents Rb phosphorylation and arrests cells at G1 and G2 phases to repress DNA replication. As major transcriptional target downstream of p53, p21 is strongly induced upon genotoxic stress to enforce cell-cycle checkpoint. p21 also interacts with PCNA to directly suppress DNA polymerase activity. Beyond tumor-suppression, p21 modulates cell differentiation and stem-cell homeostasis, and exhibits context-dependent dual roles in cancers.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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