Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-p27 KIP 1 Rabbit mAb [34C83]
抗p27 KIP 1兔单克隆抗体 [34C83]
Cat. No.
A52255
Clone No. 34C83
Synonymsp27 KIP 1, p27-Kip1, p27, KIP1, CDK2I
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
27 kDa
Observed MW
27 kDa
Clonality
Monoclonal
Clone No.
34C83
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDKN1B
Protein Name
Cyclin-dependent kinase inhibitor-1B
Background
p27KIP1 (CDKN1B, cyclin-dependent kinase inhibitor 1B) is a Cip/Kip-family CDK inhibitor mediating G1-phase repression, proliferation restraint and differentiation. p27KIP1 binds and suppresses Cyclin E-CDK2 and Cyclin A-CDK2 complexes, blocks Rb phosphorylation and restrains G1-S transition. Its abundance is mainly governed by post-translational degradation: mitogenic signals trigger ubiquitin-proteasome-dependent p27 turnover to permit proliferation. Anti-proliferative stimuli stabilize p27 and induce cell-cycle arrest. Acting as tumor suppressor, p27 down-regulation is frequent in human cancers and correlates with poor prognosis. It also modulates cell migration and autophagy.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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