Anti-Caspase-9 Mouse mAb [96E74]
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Anti-p38 MAPK (phospho Thr180/Tyr182) Rabbit mAb [58F80]
抗p38 MAPK (phospho Thr180/Tyr182)兔单克隆抗体 [58F80]
Cat. No.
A52257
Clone No. 58F80
Synonymsp38 MAPK (phospho Thr180/Tyr182), p-p38(Thr180/Tyr182), p38α MAPK, p38-alpha
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
Please check the information on the tube.
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44 kDa
Observed MW
44 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
58F80
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
MAPK14
Protein Name
p38 MAPK (phospho Thr180/Tyr182)
Background
p38 MAPK (Mitogen-activated protein kinase 14) belongs to MAP kinase family and transduces cellular stress, inflammatory, apoptotic and differentiation signals. p38 is a serine-threonine kinase activated via upstream MAP2K-mediated dual phosphorylation upon pro-inflammatory cytokines, oxidative stress, UV irradiation and osmotic challenge. Activated p38 translocates into nucleus and phosphorylates transcription factors to modulate transcription of pro-inflammatory, apoptotic and cell-cycle target genes. It mediates innate immunity and cytokine production, as well as cell differentiation and senescence. Sustained p38 signaling contributes to autoimmunity, inflammatory disorders and tumor progression.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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