Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-S6K1 Rabbit mAb [82B48]
抗S6K1兔单克隆抗体 [82B48]
Cat. No.
A52259
Clone No. 82B48
SynonymsS6K1, p70 S6 kinase-1, p70-S6K, S6K1, S6K alpha
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
59 kDa
Observed MW
70 kDa
Clonality
Monoclonal
Clone No.
82B48
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RPS6KB1
Protein Name
Ribosomal protein-S6 kinase-1
Background
S6K1 (RPS6KB1, ribosomal protein S6 kinase beta-1) is an AGC-family serine-threonine kinase acting downstream of mTOR to control protein translation, cell growth and proliferation. S6K1 serves as major substrate of mTORC1. mTORC1-dependent phosphorylation activates S6K1, which further phosphorylates ribosomal protein S6 to boost translation of 5'-TOP-containing mRNAs, enhance ribosome biogenesis and drive cell hypertrophy. S6K1 also triggers negative-feedback phosphorylation of IRS1 to dampen PI3K signaling for pathway homeostasis.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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