Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PAK1 Rabbit mAb [44A52]
抗PAK1兔单克隆抗体 [44A52]
Cat. No.
A52261
Clone No. 44A52
SynonymsPAK1, p21-activated kinase 1, PAK-1, STE20-related kinase
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
61 kDa
Observed MW
61 kDa
Clonality
Monoclonal
Clone No.
44A52
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PAK1
Protein Name
p21-activated kinase-1
Background
PAK1 (p21-activated kinase 1) belongs to p21-activated serine-threonine kinase family, acting downstream of Rac/Cdc42 to orchestrate cytoskeleton remodeling, cell migration and proliferation. Autoinhibited PAK1 is relieved upon binding GTP-loaded Rac1 or Cdc42. Activated PAK1 phosphorylates downstream substrates to modulate actin assembly, promoting lamellipodia and filopodia formation, cell motility and adhesion turnover. It also crosstalks with MAPK and AKT cascades to regulate cell-cycle progression and survival. PAK1 overexpression and hyper-activation are observed in multiple human cancers and potentiate invasion and metastasis.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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