Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PAKγ Rabbit mAb [38D96]
抗PAKγ兔单克隆抗体 [38D96]
Cat. No.
A52262
Clone No. 38D96
SynonymsPAKγ, PAK-γ, p21-activated kinase 3, PAK-3, STEF
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
58 kDa
Observed MW
58 kDa
Clonality
Monoclonal
Clone No.
38D96
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PAK3
Protein Name
p21-activated kinase-3
Background
PAK3 (PAKγ, p21-activated kinase 3) is group-II p21-activated kinase family protein mediating cytoskeleton control, neurodevelopment and pro-survival signaling. As group-II PAK, PAKγ (PAK3) is regulated by Rac/Cdc42 and lacks canonical auto-inhibitory activation mode. It is highly enriched in nervous system, governing dendrite morphogenesis, synaptogenesis and neuronal migration during neural development. Its kinase activity modulates actin and microtubule dynamics. Germline PAK3 mutations cause intellectual disability. Up-regulated PAKγ in certain tumors contributes to cancer-cell invasion and apoptosis-resistance. It also participates in epithelial-cell migration beyond neuronal contexts.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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