Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Paxillin Rabbit mAb [65F58]
抗Paxillin兔单克隆抗体 [65F58]
Cat. No.
A52266
Clone No. 65F58
SynonymsPaxillin, paxillin, LCP1, focal adhesion protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
68 kDa
Observed MW
68 kDa
Clonality
Monoclonal
Clone No.
65F58
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PXN
Protein Name
Paxillin
Background
Paxillin is focal-adhesion scaffold-adaptor protein family mediating focal-adhesion assembly and signal integration for cell adhesion and migration. Localized at focal adhesion complexes, paxillin contains multiple SH2/SH3-binding motifs, recruiting FAK, Src and diverse adaptors to build adhesion signaling hubs, transmitting integrin-extracellular-matrix signals inward. It orchestrates actin cytoskeleton rearrangement and governs cell spreading, migration and invasion. Tyrosine phosphorylation dynamically reshapes paxillin protein-protein interactions. Dysregulated paxillin expression and phosphorylation drive tumor metastasis.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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