Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Pyruvate Dehydrogenase E1α Rabbit mAb [24H31]
抗Pyruvate Dehydrogenase E1α兔单克隆抗体 [24H31]
Cat. No.
A52268
Clone No. 24H31
SynonymsPyruvate Dehydrogenase E1α, PDH-E1α, pyruvate dehydrogenase E1 subunit alpha, PDH-E1α, PDHA1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
43 kDa
Observed MW
43 kDa
Clonality
Monoclonal
Clone No.
24H31
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PDHA1
Protein Name
Pyruvate dehydrogenase E1 subunit alpha-1
Background
PDHA1 (Pyruvate dehydrogenase E1 subunit alpha) is E1-alpha subunit of pyruvate dehydrogenase complex, acting at metabolic hub to catalyze oxidative decarboxylation of pyruvate into acetyl-CoA. Residing in mitochondrial matrix, PDHA1 constitutes E1 component of pyruvate dehydrogenase complex and bridges glycolysis and TCA cycle. Its catalytic activity is switched off by phosphorylation and restored upon dephosphorylation, serving as central metabolic checkpoint. PDHA1 deficiency causes mitochondrial metabolic disorders. In many tumors, PDHA1 activity is repressed to facilitate Warburg effect and enhance glycolysis.
Localization
Mitochondrion
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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