Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PERK Rabbit mAb [13B01]
抗PERK兔单克隆抗体 [13B01]
Cat. No.
A52269
Clone No. 13B01
SynonymsPERK, eIF2α kinase 3, ERN2, protein kinase RNA-like ER kinase
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
125 kDa
Observed MW
140 kDa
Clonality
Monoclonal
Clone No.
13B01
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
EIF2AK3
Protein Name
Protein kinase RNA-like endoplasmic reticulum kinase
Background
EIF2AK3 (PERK, eukaryotic translation initiation factor 2-alpha kinase 3) belongs to endoplasmic-reticulum stress-sensing kinase family and transduces unfolded-protein-response (UPR) signals to govern translation and cell fate. Embedded in ER membrane, PERK senses luminal protein-folding stress via its N-terminal domain and becomes activated through dimerization and autophosphorylation. Active PERK phosphorylates eIF2α to globally attenuate mRNA translation and alleviate ER protein burden. Under sustained ER stress, PERK-dependent CHOP up-regulation triggers apoptotic execution. PERK also modulates lipid metabolism and pancreatic β-cell homeostasis; its dysregulation contributes to diabetes, neurodegeneration and malignancy.
Localization
Endoplasmic Reticulum
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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