Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PGP9.5 Rabbit mAb [21B86]
抗PGP9.5兔单克隆抗体 [21B86]
Cat. No.
A52273
Clone No. 21B86
SynonymsPGP9.5, UCH-L1, ubiquitin carboxyl-terminal hydrolase L1, deubiquitinating enzyme
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
25 kDa
Observed MW
25 kDa
Clonality
Monoclonal
Clone No.
21B86
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
UCHL1
Protein Name
Ubiquitin carboxyl-terminal hydrolase-L1
Background
UCHL1 (PGP9.5, ubiquitin C-terminal hydrolase L1) is a ubiquitin C-terminal hydrolase family protein mediating de-ubiquitination and ubiquitin recycling. Highly enriched in neurons and neuroendocrine cells, PGP9.5 serves as well-established mature-neuron biomarker. As DUB enzyme, it catalyzes substrate de-ubiquitination and maintains cellular free-ubiquitin pool for protein turnover. Upon neural injury or neurodegeneration, PGP9.5 leaks into extracellular space and elevates cerebrospinal-fluid level. It labels nerve fibers, enteric nervous system and neuroendocrine neoplasms.
Localization
Cytoplasm
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:400
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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