Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PI3-Kinase p85α Rabbit mAb [58C43]
抗PI3-Kinase p85α兔单克隆抗体 [58C43]
Cat. No.
A52275
Clone No. 58C43
SynonymsPI3-Kinase p85α, PI3K-p85α, PI3K regulatory subunit alpha, p85α, PIK3R1, phosphoinositide-3-kinase regulatory subunit p85-alpha
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
84 kDa
Observed MW
84 kDa
Clonality
Monoclonal
Clone No.
58C43
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PIK3R1
Protein Name
Phosphatidylinositol 3-kinase regulatory subunit-alpha
Background
PIK3R1 (PI3-kinase p85α, phosphoinositide-3-kinase regulatory subunit alpha) belongs to PI3K regulatory-subunit family and assembles PI3K holoenzyme for RTK-downstream signal transduction. As regulatory component of PI3K heterodimer, p85α harbors SH2 domains that bind phosphorylated tyrosine residues on activated receptor tyrosine kinases. It recruits p110 catalytic subunit to plasma membrane to trigger PI3K activity, converting PIP2 into PIP3 and initiating AKT signaling. Free p85α exerts inhibitory effect on p110 to keep pathway quiescent. Mutation and dysregulation of p85α are linked to malignancy and immune disorders.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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