Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PKC-α Rabbit mAb [17F22]
抗PKC-α兔单克隆抗体 [17F22]
Cat. No.
A52277
Clone No. 17F22
SynonymsPKC-α, Protein kinase C alpha, PKC-alpha, PKCA
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
77 kDa
Observed MW
77 kDa
Clonality
Monoclonal
Clone No.
17F22
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PRKCA
Protein Name
Protein kinase C-alpha
Background
PRKCA (PKCα, protein kinase C alpha) belongs to conventional protein-kinase-C family and mediates Ca2+- and diacylglycerol-dependent signaling controlling proliferation, migration and apoptosis. In resting cells PKCα resides in cytosol. Elevated intracellular calcium together with DAG production drives PKCα plasma-membrane translocation and activation. Phosphorylation of downstream substrates transduces signals downstream of GPCR and growth-factor receptors. PKCα orchestrates cytoskeleton remodeling, cell adhesion and cell-cycle progression. Its biological output is context-dependent, promoting either proliferation or apoptosis. Altered PKCα expression and activity occur in tumorigenesis and cardiovascular diseases.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:500-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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