Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PKM Rabbit mAb [95E56]
抗PKM兔单克隆抗体 [95E56]
Cat. No.
A52278
Clone No. 95E56
SynonymsPKM, Pyruvate kinase M1/M2, PK-M2, PKM2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
57 kDa
Observed MW
57 kDa
Clonality
Monoclonal
Clone No.
95E56
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PKM
Protein Name
Pyruvate kinase M2
Background
PKM (Pyruvate kinase M) represents alternatively spliced isoforms of pyruvate kinase M family catalyzing final glycolytic step and governing cancer metabolic reprogramming. Alternative splicing yields PKM1 and PKM2. Tetrameric PKM1 exhibits high catalytic activity and drives glycolysis in differentiated normal tissues. PKM2 toggles between tetramer and dimer conformations; low-activity dimeric PKM2 accumulates in tumor cells and underpins Warburg effect. Beyond glycolytic catalysis, nuclear-translocated PKM2 acts as transcriptional co-regulator for proliferative genes. Tumors undergo isoform-switch toward PKM2 to sustain rapid growth.
Localization
Cytoplasm, Nucleus
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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