Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PMS2 Rabbit mAb [92C21]
抗PMS2兔单克隆抗体 [92C21]
Cat. No.
A52279
Clone No. 92C21
SynonymsPMS2, PMS1 homolog 2, PMS2 homolog
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
96 kDa
Observed MW
110 kDa
Clonality
Monoclonal
Clone No.
92C21
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PMS2
Protein Name
PMS2 mismatch repair protein
Background
PMS2 (PMS2 homolog 2, mismatch-repair protein) belongs to mismatch-repair (MMR) protein family and corrects DNA replication errors to preserve genome integrity. As subunit of MutLα heterodimer, PMS2 heterodimerizes with MLH1. Together with MutS complexes, it recognizes base mismatches and insertion-deletion loops and initiates excision-repair of erroneous DNA segments. PMS2 protein stability strictly depends on MLH1; PMS2 is rapidly degraded upon MLH1 loss. Inactivating PMS2 mutation causes defective mismatch repair and microsatellite instability (MSI), driving Lynch syndrome and drastically elevating risk for colorectal and endometrial carcinoma. IHC-P serves as key clinical-pathology MMR screening assay.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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