Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Peroxiredoxin 1 Rabbit mAb [64G20]
抗Peroxiredoxin 1兔单克隆抗体 [64G20]
Cat. No.
A52283
Clone No. 64G20
SynonymsPeroxiredoxin 1, PRDX1, Peroxiredoxin-1, PRX-1, PRX1, AIIF2A6
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
22 kDa
Observed MW
26 kDa
Clonality
Monoclonal
Clone No.
64G20
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PRDX1
Protein Name
Peroxiredoxin-1
Background
PRDX1 (Peroxiredoxin-1) is 2-Cys peroxiredoxin family protein eliminating intracellular hydrogen peroxide and peroxynitrite to counteract oxidative stress. Using thiol-dependent catalysis, PRDX1 reduces H2O2 and lipid peroxides to mitigate oxidative insults. It undergoes conformational transitions among monomer, dimer and high-order oligomer; hyperoxidation under heavy oxidative stress triggers catalytic inactivation. Predominantly cytosolic with minor nuclear pool, PRDX1 also shapes redox-dependent signaling and modulates NF-κB activity. Aberrant PRDX1 expression associates with inflammation and malignancy; PRDX1 up-regulation confers resistance to oxidative and chemotherapeutic stress in cancers.
Localization
Cytoplasm
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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