Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Prohibitin Rabbit mAb [19A87]
抗Prohibitin兔单克隆抗体 [19A87]
Cat. No.
A52284
Clone No. 19A87
SynonymsProhibitin, PHB, Prohibitin, PHB1, BHS-73
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
30 kDa
Observed MW
30 kDa
Clonality
Monoclonal
Clone No.
19A87
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PHB
Protein Name
Prohibitin
Background
PHB (Prohibitin, prohibitin-1) belongs to prohibitin membrane-scaffold family governing mitochondrial homeostasis, transcriptional regulation and cell-cycle repression. PHB accumulates on inner mitochondrial membrane and forms hetero-oligomeric assemblies with PHB2. The complex sustains inner-membrane architecture, assists respiratory-complex biogenesis and preserves mitochondrial morphology. A subset of PHB translocates into nucleus to modulate transcription-factor activity and repress proliferation. PHB participates in senescence and apoptosis; dysregulated PHB shows context-dependent tumor-suppressive or oncogenic roles dictated by subcellular localization. It also functions as cell-surface receptor for extracellular cues.
Localization
Mitochondrion
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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