Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PTEN Rabbit mAb [51C33]
抗PTEN兔单克隆抗体 [51C33]
Cat. No.
A52285
Clone No. 51C33
SynonymsPTEN, Phosphatase and tensin homolog, MMAC1, TEP1, TEN1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
47 kDa
Observed MW
56 kDa
Clonality
Monoclonal
Clone No.
51C33
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PTEN
Protein Name
Phosphatase and tensin homolog
Background
PTEN (Phosphatase and tensin homolog) is a dual-specificity phosphatase tumor-suppressor family protein that dephosphorylates PIP3 to negatively restrain PI3K-AKT signaling. PTEN converts plasma-membrane PIP3 back to PIP2 to counteract PI3K output and constrain excessive AKT-driven proliferation, survival and metabolism. It also exhibits protein-phosphatase activity. Genomic deletion, mutation or epigenetic silencing of PTEN represents one of the most frequent tumor-suppressor defects in human cancers. Germline PTEN mutations cause PTEN hamartoma tumor syndrome. PTEN shuttles between cytoplasm and nucleus; nuclear PTEN preserves genome stability.
Localization
Cytoplasm
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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