Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Rab5A Rabbit mAb [11B14]
抗Rab5A兔单克隆抗体 [11B14]
Cat. No.
A52286
Clone No. 11B14
SynonymsRab5A, RAB5A, RAS-like protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
24 kDa
Observed MW
24 kDa
Clonality
Monoclonal
Clone No.
11B14
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RAB5A
Protein Name
RAB5A, member RAS oncogene family
Background
RAB5A (Ras-related protein Rab-5A) belongs to Rab small-GTPase family and orchestrates early-endosome biogenesis, endocytic trafficking and endosomal membrane fusion. Acting as molecular switch, GTP-bound active Rab5A localizes on early-endosome membrane, recruits downstream effectors and drives fusion between endocytic vesicles and early endosomes. It governs cargo sorting, receptor degradation and recycling, and modulates growth-factor-receptor endocytosis. GDP-loaded Rab5A resides within cytosol. Dysregulated Rab5A perturbs endocytic routes, alters receptor turnover and contributes to tumor-cell migration.
Localization
Endosome
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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