Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Rab7 Rabbit mAb [02D12]
抗Rab7兔单克隆抗体 [02D12]
Cat. No.
A52287
Clone No. 02D12
SynonymsRab7, RAB7A, RAS-like protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
24 kDa
Observed MW
24 kDa
Clonality
Monoclonal
Clone No.
02D12
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RAB7A
Protein Name
RAB7A, member RAS oncogene family
Background
RAB7A (Rab7, Ras-related protein Rab-7A) belongs to Rab small-GTPase family controlling late-endosome maturation, late-endosome-lysosome fusion and degradative trafficking. As signature GTPase for late endosomes, GTP-charged Rab7 localizes to late-endosome membrane, drives early-to-late endosome conversion, recruits effectors and promotes late-endosome-lysosome fusion for cargo degradation. It also supports autolysosome biogenesis and participates in nutrient handling, receptor turnover and selective autophagy. Loss-of-function Rab7 blocks endo-lysosomal flux and contributes to neurodegeneration.
Localization
Endosome, Lysosome
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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