Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Rad21 Rabbit mAb [21D93]
抗Rad21兔单克隆抗体 [21D93]
Cat. No.
A52288
Clone No. 21D93
SynonymsRad21, RAD21 cohesin complex component, Scc1, P150
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
72 kDa
Observed MW
130 kDa
Clonality
Monoclonal
Clone No.
21D93
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RAD21
Protein Name
RAD21 cohesin complex component
Background
RAD21 (RAD21 cohesin complex component) is core subunit of cohesin complex, mediating sister-chromatid cohesion, DNA-damage repair and transcriptional regulation. As essential cohesin component, RAD21 physically tethers sister chromatids during S-phase and ensures accurate mitotic chromosome segregation. At anaphase, separase-mediated RAD21 cleavage resolves chromatid linkage. RAD21 also participates in homologous-recombination repair of double-strand breaks, shapes chromatin loops and topologically-associated domains and modulates gene transcription. Defective RAD21 induces chromosome mis-segregation and genomic instability frequently observed in cancers.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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