Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Rb Rabbit mAb [56A63]
抗Rb兔单克隆抗体 [56A63]
Cat. No.
A52291
Clone No. 56A63
SynonymsRb, Retinoblastoma protein, pRb
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
106 kDa
Observed MW
110 kDa
Clonality
Monoclonal
Clone No.
56A63
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RB1
Protein Name
Retinoblastoma protein
Background
RB1 (Rb, Retinoblastoma-associated protein) is retinoblastoma tumor-suppressor protein family governing G1/S cell-cycle checkpoint via repressing E2F transcription factors. Under quiescent conditions, hypophosphorylated Rb sequesters E2F and silences S-phase-associated genes to block S-phase entry. Cyclin-CDK-dependent hyper-phosphorylation dissociates Rb-E2F complex, liberating E2F to drive transcription of DNA-replication genes and permit G1-S transition. Inactivation of Rb pathway represents a frequent oncogenic event triggered by gene deletion, mutation or upstream hyper-phosphorylation. Beyond cell-cycle control, Rb modulates differentiation, apoptosis and senescence.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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