Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-RIP Rabbit mAb [15A66]
抗RIP兔单克隆抗体 [15A66]
Cat. No.
A52293
Clone No. 15A66
SynonymsRIP, RIPK1, Receptor-interacting serine/threonine-protein kinase 1, RIP1, IKKAP1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
76 kDa
Observed MW
76 kDa
Clonality
Monoclonal
Clone No.
15A66
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RIPK1
Protein Name
Receptor-interacting serine/threonine-protein kinase-1
Background
RIPK1 (RIP, Receptor-interacting serine-threonine kinase 1) belongs to receptor-interacting kinase family transducing TNFR-downstream signals and governing NF-κB-driven inflammation, apoptosis and necroptosis. Equipped with kinase and death domains, RIPK1 is recruited to TNF-R1 complex upon TNF-α stimulation. Ubiquitinated RIPK1 assembles Complex-I to trigger NF-κB activation supporting inflammation and cell survival. Upon de-ubiquitination it translocates to form Complex-II initiating caspase-dependent apoptosis. When caspase-8 is suppressed, RIPK1 interacts with RIPK3 to drive necroptosis. RIPK1 contributes to inflammatory disorders and tumor progression.
Localization
Cytoplasm
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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