Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-p90RSK (phospho Thr359/Ser363) Rabbit mAb [14E50]
抗p90RSK (phospho Thr359/Ser363)兔单克隆抗体 [14E50]
Cat. No.
A52295
Clone No. 14E50
Synonymsp90RSK (phospho Thr359/Ser363), p-p90RSK(Thr359/Ser363), p90RSK, RSK1, Ribosomal protein S6 kinase A1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
83 kDa
Observed MW
83 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
14E50
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RPS6KA1
Protein Name
p90RSK (phospho Thr359/Ser363)
Background
RPS6KA1 (p90RSK, 90 kDa ribosomal S6 kinase) is RSK serine-threonine kinase family acting downstream of ERK to transduce proliferative and pro-survival signals. Thr359/Ser363 resides within C-terminal kinase domain of p90RSK. ERK-dependent dual-site phosphorylation at these residues is critical for full-length p90RSK activation, which subsequently activates N-terminal kinase domain to phosphorylate diverse cytoplasmic and nuclear substrates governing transcription, cell-cycle progression and anti-apoptosis. It responds to growth-factor and MAPK inputs; hyper-activation contributes to oncogenic proliferation.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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