Anti-RSK2 Rabbit mAb [06F72]

Protein A affinity purification

Ribosomal protein S6 kinase-2

RPS6KA3 (RSK2, ribosomal S6 kinase 2) is p90RSK-family isoform, dual-domain serine-threonine kinase downstream of ERK mediating proliferation, transcriptional control and stress responses. RSK2 possesses N-terminal and C-terminal kinase domains. ERK-dependent phosphorylation activates C-terminal domain which in turn triggers N-terminal-domain activation. Active RSK2 phosphorylates substrates such as CREB and c-Fos to regulate immediate-early-gene transcription. It plays essential roles in bone development; germline RSK2 loss-of-function causes Coffin-Lowry syndrome. Dysregulated RSK2 activation promotes tumor proliferation and invasion.

Cytoplasm, Nucleus