Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-RUNX2 Rabbit mAb [96A59]
抗RUNX2兔单克隆抗体 [96A59]
Cat. No.
A52297
Clone No. 96A59
SynonymsRUNX2, Runt-related transcription factor 2, CBFA1, AML3
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
57 kDa
Observed MW
57 kDa
Clonality
Monoclonal
Clone No.
96A59
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
RUNX2
Protein Name
Runt-related transcription factor-2
Background
RUNX2 (Runt-related transcription factor 2) is Runt-family master transcription factor governing osteogenic differentiation, bone-matrix-gene expression and osteoblast maturation. Predominantly nuclear-localized, RUNX2 binds promoters and enhancers of osteogenic genes and drives transcription of osteocalcin, collagen-I and other targets, determining mesenchymal-stem-cell commitment toward osteoblast lineage and controlling skeletal development and bone remodeling. Germline RUNX2 mutation causes cleidocranial dysplasia. Aberrant RUNX2 expression in tumors contributes to EMT and bone metastasis.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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