Anti-S100B Rabbit mAb [30B91]

抗S100B兔单克隆抗体 [30B91]

Cat. No. A52298 Clone No. 30B91

SynonymsS100B, S100 calcium-binding protein B, B-protrein, S100 beta

Host species Rabbit
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, ELISA

详细信息 Product Information

Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
11 kDa
Observed MW
11 kDa
Clonality
Monoclonal
Clone No.
30B91
Isotype
IgG, Kappa

抗原与靶点信息 Antigen & Target Information

Gene Name
S100B
Protein Name
S100 calcium-binding protein-B
Background
S100B (S100 calcium-binding protein B) belongs to S100 calcium-sensor-protein family acting as Ca2+-dependent signaling modulator for proliferation, apoptosis and migration, and also serving as neural-injury biomarker. S100B is mainly produced by astrocytes, Schwann cells and subsets of neuroendocrine cells. Ca2+-binding induces conformational rearrangement enabling interaction with intracellular targets to modulate cytoskeleton and kinase cascades. It can also be secreted extracellularly as DAMP molecule. Upon brain trauma or hemorrhage, S100B leaks into blood and cerebrospinal fluid and serves as clinical neural-damage indicator. It also contributes to melanoma progression.
Localization
Cytoplasm, Nucleus
Research Area
神经科学
数据库链接
物种 Organism基因 IDSwissProt
Human 6285 P04271
Mouse P50114

实验信息 Product Usage & Documents

推荐稀释比 Recommended Dilution

WB
1:2000-1:10000
IHC
1:400-1:2000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议,实际需按样本类型与显色体系优化。

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