50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
11 kDa
Observed MW
11 kDa
Clonality
Monoclonal
Clone No.
30B91
Isotype
IgG, Kappa
抗原与靶点信息
Antigen & Target Information
Gene Name
S100B
Protein Name
S100 calcium-binding protein-B
Background
S100B (S100 calcium-binding protein B) belongs to S100 calcium-sensor-protein family acting as Ca2+-dependent signaling modulator for proliferation, apoptosis and migration, and also serving as neural-injury biomarker. S100B is mainly produced by astrocytes, Schwann cells and subsets of neuroendocrine cells. Ca2+-binding induces conformational rearrangement enabling interaction with intracellular targets to modulate cytoskeleton and kinase cascades. It can also be secreted extracellularly as DAMP molecule. Upon brain trauma or hemorrhage, S100B leaks into blood and cerebrospinal fluid and serves as clinical neural-damage indicator. It also contributes to melanoma progression.