Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-SDHA Rabbit mAb [66F25]
抗SDHA兔单克隆抗体 [66F25]
Cat. No.
A52299
Clone No. 66F25
SynonymsSDHA, SDH2, SDHF, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Flavoprotein subunit of complex II, Fp
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
73 kDa
Observed MW
73 kDa
Clonality
Monoclonal
Clone No.
66F25
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SDHA
Protein Name
Succinate dehydrogenase complex flavoprotein subunit A
Background
SDHA (Succinate dehydrogenase complex flavoprotein subunit A) is catalytic flavoprotein subunit of mitochondrial complex II residing on inner mitochondrial membrane, coupling tricarboxylic-acid-cycle catalysis with respiratory-chain electron transfer. SDHA constitutes catalytic core of complex II, oxidizing succinate into fumarate and transferring electrons to ubiquinone, linking TCA cycle and oxidative phosphorylation. SDHA deficiency impairs complex II activity leading to succinate accumulation, inhibiting α-KG-dependent dioxygenases and triggering epigenetic reprogramming characteristic of SDH-deficient neoplasms. SDHA is also widely used as reference marker for mitochondrial integrity.
Localization
Mitochondrion
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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