Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-SIRT1 Rabbit mAb [01F80]
抗SIRT1兔单克隆抗体 [01F80]
Cat. No.
A52300
Clone No. 01F80
SynonymsSIRT1, Sirtuin 1, SIR2 homolog 1, NAD-dependent deacetylase Sir2-related protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
81 kDa
Observed MW
130 kDa
Clonality
Monoclonal
Clone No.
01F80
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SIRT1
Protein Name
Sirtuin-1
Background
SIRT1 (Sirtuin-1) is NAD+-dependent class-III histone-deacetylase family protein catalyzing deacetylation of histones and non-histone substrates to govern senescence, metabolism, DNA-damage response and inflammation. Predominantly nuclear-localized, SIRT1 consumes NAD+ co-factor to erase acetyl-modifications from histones, p53, FOXO, NF-κB and other targets, regulating transcription, cell-cycle control, DNA repair and lipid-glucose homeostasis. SIRT1 senses cellular NAD+ status and mediates metabolic outputs linked to caloric restriction and ageing. It displays context-dependent tumor-suppressive or oncogenic roles in malignancies.
Localization
Nucleus
Research Area
表观遗传学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:200
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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