Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-SIRT3 Rabbit mAb [18C83]
抗SIRT3兔单克隆抗体 [18C83]
Cat. No.
A52301
Clone No. 18C83
SynonymsSIRT3, Sirtuin 3, mitochondrial
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44 kDa
Observed MW
28 kDa
Clonality
Monoclonal
Clone No.
18C83
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SIRT3
Protein Name
Sirtuin-3
Background
SIRT3 (Sirtuin-3) is mitochondrially-targeted NAD+-dependent deacetylase family protein mediating matrix-protein deacetylation to modulate oxidative phosphorylation, antioxidant defence and metabolic reprogramming. SIRT3 precursor is translated in cytosol, imported into mitochondrial matrix and proteolytically processed into active form. It deacetylates respiratory-complex subunits, IDH2, SOD2 and other matrix proteins, boosting mitochondrial antioxidant capacity and tuning TCA-cycle and fatty-acid oxidation. SIRT3 mitigates ROS burden and sustains mitochondrial homeostasis; its expression declines in ageing and metabolic disorders. In tumors SIRT3 exerts dual effects: it counteracts oxidative genome damage yet can sustain oncogenic metabolism.
Localization
Mitochondrion
Research Area
表观遗传学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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