Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Slug Rabbit mAb [42E17]
抗Slug兔单克隆抗体 [42E17]
Cat. No.
A52303
Clone No. 42E17
SynonymsSlug, Snail family transcriptional repressor 2, SIP-1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
30 kDa
Observed MW
36 kDa
Clonality
Monoclonal
Clone No.
42E17
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SNAI2
Protein Name
Snail family transcriptional repressor-2
Background
SNAI2 (Slug, Snail family transcriptional repressor 2) is Snail-family zinc-finger transcriptional repressor acting as master EMT regulator, silencing epithelial genes and activating mesenchymal programs. Nuclear-localized Slug binds E-box motifs within promoters of epithelial genes such as E-cadherin to repress their transcription while up-regulating mesenchymal-signature genes, conferring migratory-invasive cellular phenotype. Slug participates in embryonic morphogenesis and wound healing. Tumors frequently up-regulate Slug to promote EMT, metastasis and chemoresistance.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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