Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Smad1 Rabbit mAb [76C06]
抗Smad1兔单克隆抗体 [76C06]
Cat. No.
A52304
Clone No. 76C06
SynonymsSmad1, SMAD1, MAD homolog 1, DPP homolog 1, MAD1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
52 kDa
Observed MW
52 kDa
Clonality
Monoclonal
Clone No.
76C06
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SMAD1
Protein Name
Mothers against decapentaplegic homolog-1
Background
SMAD1 (SMAD family member 1) belongs to BMP-pathway receptor-activated R-Smad family transducing intracellular BMP signals governing osteogenic differentiation, proliferation and apoptosis. Upon BMP-receptor activation, Smad1 is phosphorylated at C-terminal SSXS motif. Phospho-Smad1 heteroligomerizes with Smad4 and translocates into nucleus to bind regulatory elements and drive BMP-dependent transcriptional responses controlling mesenchymal osteogenic commitment and embryogenesis. Smad1 activity is tightly restrained by ubiquitination and de-phosphorylation. Pathway dysregulation links to bone-metabolic disorders and malignancy.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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