Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Smad2 Rabbit mAb [45B16]
抗Smad2兔单克隆抗体 [45B16]
Cat. No.
A52306
Clone No. 45B16
SynonymsSmad2, SMAD2, Mothers against DPP homolog 2, MAD homolog 2, DMH2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
58 kDa
Observed MW
58 kDa
Clonality
Monoclonal
Clone No.
45B16
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SMAD2
Protein Name
SMAD family member-2
Background
SMAD2 (Smad2) is receptor-activated R-Smad for TGF-β/Activin-signaling transducing TGF-β-superfamily inputs to control proliferation, differentiation, EMT and apoptosis. Upon TGF-β-receptor engagement, type-I receptor kinase phosphorylates Smad2 C-terminal SSXS motif. Activated Smad2 heterocomplexes with Smad4 and shuttles into nucleus, associating with transcriptional co-activators/co-repressors to govern target-gene expression. In resting cells Smad2 predominantly resides in cytosol; TGF-β challenge triggers nuclear translocation. Smad2 pathway exerts tumor-suppressive effects in early-stage neoplasia yet drives EMT-metastasis in advanced tumors.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
相关产品 Related Products
Anti-IL-1β Rabbit mAb [99F42]
WBIPIFELISA
Anti-Polycomb Protein SUZ12 Rabbit mAb [36G88]
WBIHCIPIFELISA
价格与规格
该产品暂未录入规格价格，请联系我们获取报价与现货情况。