Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Snail Rabbit mAb [01A36]
抗Snail兔单克隆抗体 [01A36]
Cat. No.
A52311
Clone No. 01A36
SynonymsSnail, AI1, EB1, E4BP4, SNAI
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
29 kDa
Observed MW
29 kDa
Clonality
Monoclonal
Clone No.
01A36
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SNAI1
Protein Name
Snail family transcriptional repressor-1
Background
SNAI1 (Snail, Snail family transcriptional repressor 1) is zinc-finger transcriptional repressor and master EMT regulator, silencing epithelial-signature genes and activating mesenchymal programs. Nuclear-localized Snail recognizes E-box motifs within target-gene promoters and directly represses transcription of epithelial markers such as E-cadherin, conferring migratory and invasive cellular phenotypes. It participates in embryonic gastrulation and wound healing. Tumors frequently up-regulate Snail to drive EMT, distant metastasis and chemoresistance. Snail exhibits short half-life and its stability is tightly controlled by ubiquitin-proteasome system.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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