Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-SOD1 Rabbit mAb [31F33]
抗SOD1兔单克隆抗体 [31F33]
Cat. No.
A52312
Clone No. 31F33
SynonymsSOD1, Cu/Zn superoxide dismutase, SODC, ALS4
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
23 kDa
Observed MW
15 kDa
Clonality
Monoclonal
Clone No.
31F33
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SOD1
Protein Name
Superoxide dismutase-1, cytosolic
Background
SOD1 (Superoxide dismutase 1, Cu/Zn-SOD) is Cu-Zn-dependent superoxide dismutase catalyzing cytosolic superoxide-anion scavenging to counteract oxidative insults. Predominantly cytosolic with minor pool in mitochondrial intermembrane space, SOD1 uses Cu-Zn co-factors to dismutate superoxide radicals into oxygen and hydrogen peroxide, constituting primary cellular antioxidant defence. Germline SOD1 mutations are well-known drivers of amyotrophic lateral sclerosis (ALS). Under oxidative stress SOD1 misfolds and aggregates to exert neurotoxicity. Altered SOD1 expression reshapes ROS homeostasis and modulates proliferation and drug response in cancers.
Localization
Cytoplasm
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:100-1:5000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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