Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-SOX9 Rabbit mAb [32F83]
抗SOX9兔单克隆抗体 [32F83]
Cat. No.
A52314
Clone No. 32F83
SynonymsSOX9, SRY-box 9
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
56 kDa
Observed MW
70 kDa
Clonality
Monoclonal
Clone No.
32F83
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SOX9
Protein Name
SRY-box transcription factor-9
Background
SOX9 (SRY-box transcription factor 9) is HMG-box containing SOX-family transcription factor acting as master chondrogenic regulator governing mesenchymal-to-chondrocyte differentiation and gonadal development. Nuclear-localized SOX9 binds enhancers of cartilage-specific genes and drives transcription of type-II collagen, aggrecan and other matrix genes to orchestrate chondrogenesis; it also participates in sex-determination pathways. Loss-of-function SOX9 mutations cause campomelic dysplasia. Aberrant SOX9 activation in tumours sustains stem-cell-like properties and promotes proliferation, EMT and metastasis; its overexpression is observed in hepatocellular carcinoma, colorectal cancer and other malignancies.
Localization
Nucleus
Research Area
干细胞
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:1000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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