Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-SQSTM1/p62 Rabbit mAb [60F08]
抗SQSTM1/p62兔单克隆抗体 [60F08]
Cat. No.
A52316
Clone No. 60F08
SynonymsSQSTM1/p62, p62 / SQSTM1, p62, DDBP, sequestosome 1, AIP1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
48 kDa
Observed MW
60 kDa
Clonality
Monoclonal
Clone No.
60F08
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SQSTM1
Protein Name
Sequestosome-1
Background
SQSTM1 (p62, Sequestosome-1) is multifunctional adaptor protein mediating selective-autophagy substrate recognition, signal transduction and oxidative-stress responses. Acting as autophagy receptor, p62 binds ubiquitinated cargo and LC3 simultaneously to target ubiquitinated substrates for selective autophagic degradation. When autophagic flux is intact, p62 is degraded together with cargo inside lysosomes; autophagy blockade leads to massive p62 accumulation. p62 also modulates Nrf2 antioxidant axis, mTOR and NF-κB inflammatory cascades. It is implicated in protein-aggregation disorders and malignancy. p62 abundance is widely adopted to evaluate autophagic-flux status.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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