Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STAT1α Rabbit mAb [58E24]
抗STAT1α兔单克隆抗体 [58E24]
Cat. No.
A52317
Clone No. 58E24
SynonymsSTAT1α, STAT1-α, STAT91, transcription factor AP-2, HRS
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
87 kDa
Observed MW
90 kDa
Clonality
Monoclonal
Clone No.
58E24
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
STAT1
Protein Name
Signal transducer and activator of transcription-1 α isoform
Background
STAT1 α (Signal transducer and activator of transcription 1 α) is JAK-STAT-family transcription factor transducing interferon-driven signals to govern antiviral immunity, cell-cycle arrest, pro-apoptotic programmes and anti-tumour immunity. Upon interferon stimulation, JAK-mediated tyrosine phosphorylation triggers STAT1-α homodimerization, nuclear translocation and binding to ISG promoters to induce interferon-stimulated-gene expression and exert antiviral and anti-proliferative outputs. STAT1-α represents full-length functional STAT1 isoform. Loss-of-function STAT1 defects compromise host antiviral defence.
Localization
Cytoplasm, Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:500-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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