Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STAT2 Rabbit mAb [52B68]
抗STAT2兔单克隆抗体 [52B68]
Cat. No.
A52318
Clone No. 52B68
SynonymsSTAT2, STAT92, p92, ISGF3 gamma
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
98 kDa
Observed MW
113 kDa
Clonality
Monoclonal
Clone No.
52B68
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
STAT2
Protein Name
Signal transducer and activator of transcription-2
Background
STAT2 (Signal transducer and activator of transcription 2) is JAK-STAT-family transcription factor specialized for type-I interferon (IFN-α/β) signal transduction. Following type-I-interferon receptor activation, JAK kinases phosphorylate STAT2 and STAT1. STAT1-STAT2 heterodimer associates with IRF9 to assemble ISGF3 complex, which translocates into nucleus and targets ISRE motifs to drive interferon-stimulated-gene transcription and establish cellular antiviral state. STAT2 is indispensable for type-I-IFN responses and dispensable for IFN-γ signalling. STAT2-deficient cells lose type-I-IFN-mediated antiviral protection.
Localization
Cytoplasm, Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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