Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STAT3 Rabbit mAb [40B23]
抗STAT3兔单克隆抗体 [40B23]
Cat. No.
A52320
Clone No. 40B23
SynonymsSTAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
88 kDa
Observed MW
88 kDa
Clonality
Monoclonal
Clone No.
40B23
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
STAT3
Protein Name
Signal transducer and activator of transcription-3
Background
STAT3 (Signal transducer and activator of transcription 3) is central JAK-STAT-family transcription factor transducing cytokine- and growth-factor-derived signals to control proliferation, survival, inflammation, EMT and stem-cell homeostasis. In resting cells STAT3 resides in cytosol. Cytokine-receptor-triggered JAK activity induces Tyr705 phosphorylation, STAT3 dimerization and nuclear translocation for target-gene transcription. Ser727 phosphorylation modulates mitochondrial functions. STAT3 supports physiological homeostasis while exerting potent oncogenic effects; constitutive STAT3 activation is frequently observed in solid and haematological tumours.
Localization
Cytoplasm, Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:500
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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