Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STAT5B Rabbit mAb [72A67]
抗STAT5B兔单克隆抗体 [72A67]
Cat. No.
A52325
Clone No. 72A67
SynonymsSTAT5B, Signal transducer and activator of transcription 5B
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
90 kDa
Observed MW
90 kDa
Clonality
Monoclonal
Clone No.
72A67
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
STAT5B
Protein Name
Signal transducer and activator of transcription-5B
Background
STAT5B (Signal transducer and activator of transcription 5B) is JAK-STAT-family transcription factor predominantly transducing growth-hormone signals to govern somatic growth and hepatic metabolism. Activated by growth hormone and selected cytokines, JAK-dependent tyrosine phosphorylation drives STAT5B dimerization and nuclear translocation to regulate growth-hormone-responsive genes. Functionally distinct from STAT5A, STAT5B acts as critical component of GH-IGF-1 axis; STAT5B deficiency leads to growth retardation. Aberrant STAT5B activation contributes to haematological-tumour progression.
Localization
Cytoplasm, Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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