Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STAT6 (phospho Tyr641) Rabbit mAb [97C45]
抗STAT6 (phospho Tyr641)兔单克隆抗体 [97C45]
Cat. No.
A52327
Clone No. 97C45
SynonymsSTAT6 (phospho Tyr641), p-STAT6(Tyr641), STAT6, Signal transducer and activator of transcription 6, IL-4 Stat
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
94 kDa
Observed MW
110 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
97C45
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
STAT6
Protein Name
STAT6 (phospho Tyr641)
Background
STAT6 Tyr641 is conserved JAK-catalyzed tyrosine-activation site and specific biomarker for STAT6-pathway activation. Upon IL-4 / IL-13 receptor ligation, activated JAK phosphorylates STAT6 at Tyr641. Phosphorylated STAT6 undergoes homodimerization and nuclear translocation, binding target-gene promoters to drive transcription governing Th2-cell differentiation, M2-macrophage polarization, IgE class-switching and allergic inflammation. Tyr641 phosphorylation is prerequisite for STAT6 nuclear import and transcriptional competence.
Localization
Cytoplasm, Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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